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Search Results for " integrin β1 "

Targets Recommended: Integrin

13

抑制剂 & 化合物

12

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T16695	Pyrintegrin	Integrin	Cytoskeletal Signaling
	Pyrintegrin 是一种 β1 整合素激动剂，也是 2,4-二取代的嘧啶，可促进胚胎干细胞存活。它可用作足细胞保护剂，能增强细胞-细胞外基质 (ECM) 粘附介导的整联蛋白信号传导，具有强大的成脂作用。
T4400	DIM-C-pPhOH CDIM8	Apoptosis; Others	Apoptosis; Others
	DIM-C-pPhOH (CDIM8) 是一种核受体 4A1(NR4A1) 拮抗剂，可降低细胞增殖，对 ACHN 细胞和 786-O 细胞的IC50值分别为 13.6 μM 和 13.0 μM。它抑制癌细胞的生长和 mTOR 信号传导，诱导细胞凋亡和细胞应激。
T13473	αvβ1 integrin-IN-1	Integrin	Cytoskeletal Signaling
	αvβ1 integrin-IN-1是一种强效且具有选择性的αvβ1整合素抑制剂（IC50为0.63 nM），具有抗纤维化作用。
TP1484L	α2β1 Integrin Ligand Peptide acetate α2β1 Integrin Ligand Peptide acetate (134580-64-6)	Integrin	Cytoskeletal Signaling
	α2β1 Integrin Ligand Peptide acetate (α2β1 Integrin Ligand Peptide acetate (134580-64-6)) 是 α2β1 整合素受体的潜在拮抗剂。它与细胞膜上的 α2β1 整合素受体相互作用，介导细胞外信号进入细胞。
T36291	Integrin modulator 1
	Integrin modulator 1 is a potent and selective α4β1 integrin agonist, with an IC50 of 9.8 nM for RGD-binding α4β1. Integrin modulator 1 increases cell adhesion mediated by α4β1 integrin, with an EC50 of 12.9 nM[1]. Integrin modulator 1 (2-10 μg/mL; 30 min) significantly increases Jurkat E6.1 cell adhesion[1].Integrin modulator 1 (1-100 nM; 1 h) strongly and significantly increases ERK1/2 phosphorylation in Jurkat E6.1 cells[1].Integrin modulator 1 (1 nM-10 μM; 30 min) significantly increases the...
T40243	αvβ5 integrin-IN-1
	αvβ5 integrin-IN-1 is a first potent and selective αvβ5 integrin inhibitor (p IC 50 = 8.2) .
T79918	α7β1 integrin modulator-1	Integrin	Cytoskeletal Signaling
	α7β1integrinmodulator-1，作为一种高效的α7β1integrin调节剂，展现出在肌营养不良症研究中的应用潜力。
T63868	α5β1 integrin agonist-1
	α5β1 integrin agonist-1 是一种 α5β1 integrin 激动剂，可选择性地将 5-FU 输送到肿瘤细胞中，诱导肿瘤细胞死亡。
T73625	αvβ1 integrin-IN-1 TFA
	αvβ1integrin-IN-1 TFA (Compound C8) 为高效的αvβ1整合素选择性抑制剂，IC50值仅为0.63 nM，具备显著的抗纤维化能力。
T79792	αvβ1 integrin-IN-2	Integrin	Cytoskeletal Signaling
	αvβ1integrin-IN-2（compound 32）作为整合素ανβ1与α5β1的抑制剂，展现出高效性，其IC50值分别为0.9 nM和33 nM。此外，该化合物对其他整合素亦有抑制作用，其IC50分别为380 nM（ανβ3）、280 nM（ανβ5）、230 nM（ανβ6）、87 nM（ανβ8）。
T80529	VnP-16	Integrin	Cytoskeletal Signaling
	VnP-16 通过直接作用于β1整合素 (β1 integrin)，激活FAK，促进成骨细胞分化和活性，加速骨形成。
T78743	Anticancer agent 133	Apoptosis	Apoptosis
	Anticanceragent 133 (compound Rh2) 为一抗癌化合物，具有细胞毒性及抗转移特性。该化合物能诱导细胞周期阻滞、apoptosis 及 autophagy，且能够通过抑制 FAK调节的整合素 β1介导的 EGFR 表达来抑制肿瘤细胞的转移。
T83848	VnP-16 TFA
	VnP-16是一种合成肽段，对应vitronectin的氨基酸270-281，vitronectin是一种具有细胞附着、迁移和扩散等多功能作用的糖蛋白。该肽段在9.1 µg/cm2浓度下应用于细胞板时，能促进人类成骨细胞的附着和扩散，此效应可通过β1整合素的siRNA敲除被逆转。VnP-16诱导人类皮肤来源的间充质前体细胞和MC3T3-E1小鼠颅骨成骨前体细胞的成骨作用。在体内，VnP-16减少IL-1α诱导的骨质流失并减少小鼠颅骨中破骨细胞的数量。它还在卵巢切除引起的骨质疏失小鼠模型中增加骨矿物质密度并减少松质骨流失。

化合物

Cat.No: T16695

Target: Integrin

Cat.No: T4400

Synonym: CDIM8

Target: Apoptosis, Others

αvβ1 integrin-IN-1

Cat.No: T13473

Target: Integrin

α2β1 Integrin Ligand Peptide acetate

Cat.No: TP1484L

Synonym: α2β1 Integrin Ligand Peptide acetate (134580-64-6)

Target: Integrin

Integrin modulator 1

Cat.No: T36291

αvβ5 integrin-IN-1

Cat.No: T40243

α7β1 integrin modulator-1

Cat.No: T79918

Target: Integrin

α5β1 integrin agonist-1

Cat.No: T63868

αvβ1 integrin-IN-1 TFA

Cat.No: T73625

αvβ1 integrin-IN-2

Cat.No: T79792

Target: Integrin

Cat.No: T80529

Target: Integrin

Anticancer agent 133

Cat.No: T78743

Target: Apoptosis

Cat.No: T83848

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02159	Integrin alpha 5 beta 1 Protein, Human, Recombinant (Flag & His) Integrin alpha 5 β1,Integrin α5 β...	Human	HEK293 Cells
	Integrin alpha 5 beta 1 Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 192 kDa and the accession number is P08648&P05556-1.
TMPY-00476	ITGB1 Protein, Human, Recombinant (His) VLAB,integrin, beta 1 (fibronectin receptor, beta p...	Human	HEK293 Cells
	ITGB1 (Integrin Subunit Beta 1) is a Protein Coding gene. This gene encodes a beta subunit, which is a type 1 transmembrane protein of the integrin beta chain family. ITGB1 is a heterodimeric cell-surface receptor involved in cell functions such as proliferation, migration, invasion, and survival. ITGB1 has been recognized to play a major role in tumor growth, invasion, and metastasis. Using luciferase assays, the researcher identified ITGB1 as a direct target of miR-134. ITGB1 is a direct targe...
TMPY-02160	Integrin alpha 8 beta 1 Protein, Human, Recombinant (Flag & His) Integrin α8 β 1,integrin, α8,integrin<...	Human	HEK293 Cells
	Integrin alpha 8 beta 1 Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 196 kDa and the accession number is P53708&P05556-1.
TMPY-02158	Integrin alpha 6 beta 1 Protein, Human, Recombinant (Flag & His) Integrin α6 β 1,ITGA6B,VLA-6,integrin, α6,...	Human	HEK293 Cells
	Integrin alpha 6 beta 1 Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 198 kDa and the accession number is P23229-3&P05556-1.
TMPJ-00810	ITGA5 Protein, Human, Recombinant (His) FNRA,Integrin α-5,Integrin Alpha-F,Fibrone...	Human	HEK293 Cells
	Integrin α-5 belongs to the Integrin α chain family and contains 7 FG-GAP repeats. Integrin α-5 joins with Integrin-β1 to form a fibronectin and laminin receptor which recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. It is expressed on fibroblasts, endothelial cells, peripheral T cells and platelets. Integrin α-5 undergoes post-translational cleavage in the ext...
TMPK-00635	CDCP1 Protein, Rat, Recombinant (His) TRASK,SIMA135,UNQ2486,CD318,PRO5773,CDCP1	Rat	HEK293 Cells
	Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss of CDCP1 have been observed in the same cancer types to promote metastatic progression. CDCP1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 73.09 kDa and the accession number is D3ZVA1.
TMPK-01010	CDCP1 Protein, Mouse, Recombinant (His & Avi), Biotinylated UNQ2486,TRASK,CD318,SIMA135,CDCP1,PRO5773	Mouse	HEK293 Cells
	Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss of CDCP1 have been observed in the same cancer types to promote metastatic progression. CDCP1 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 75.3 kDa and the accession number is Q5...
TMPK-01256	CDCP1 Protein, Cynomolgus, Recombinant (His) TRASK,SIMA135,UNQ2486,CD318,PRO5773,CDCP1	Cynomolgus	HEK293 Cells
	Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss of CDCP1 have been observed in the same cancer types to promote metastatic progression. CDCP1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 73.2 kDa and the accession number is F6TPM5.
TMPK-01181	CDCP1 Protein, Human, Recombinant (His & Avi), Biotinylated CDCP1,PRO5773,TRASK,UNQ2486,SIMA135,CD318	Human	HEK293 Cells
	Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss of CDCP1 have been observed in the same cancer types to promote metastatic progression. CDCP1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 74.6 kDa and the accession number is Q9...
TMPK-01183	CDCP1 Protein, Human, Recombinant (aa 30-368, His) CDCP1,PRO5773,TRASK,CD318,UNQ2486,SIMA135	Human	HEK293 Cells
	Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss of CDCP1 have been observed in the same cancer types to promote metastatic progression. CDCP1 Protein, Human, Recombinant (aa 30-368, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 39.03 kDa and the accession number is Q9H5V8-1.
TMPK-01255	CDCP1 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated TRASK,SIMA135,UNQ2486,PRO5773,CD318,CDCP1	Cynomolgus	HEK293 Cells
	Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss of CDCP1 have been observed in the same cancer types to promote metastatic progression. CDCP1 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 75 kDa and the accession number is...
TMPK-01182	CDCP1 Protein, Human, Recombinant (hFc) CDCP1,PRO5773,TRASK,UNQ2486,SIMA135,CD318	Human	HEK293 Cells
	Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss of CDCP1 have been observed in the same cancer types to promote metastatic progression. CDCP1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 98.4 kDa and the accession number is Q9H5V8-1.

重组蛋白

Integrin alpha 5 beta 1 Protein, Human, Recombinant (Flag & His)

Cat.No: TMPY-02159

Species: Human

Expression System: HEK293 Cells

ITGB1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00476

Species: Human

Expression System: HEK293 Cells

Integrin alpha 8 beta 1 Protein, Human, Recombinant (Flag & His)

Cat.No: TMPY-02160

Species: Human

Expression System: HEK293 Cells

Integrin alpha 6 beta 1 Protein, Human, Recombinant (Flag & His)

Cat.No: TMPY-02158

Species: Human

Expression System: HEK293 Cells

ITGA5 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00810

Species: Human

Expression System: HEK293 Cells

CDCP1 Protein, Rat, Recombinant (His)

Cat.No: TMPK-00635

Species: Rat

Expression System: HEK293 Cells

CDCP1 Protein, Mouse, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-01010

Species: Mouse

Expression System: HEK293 Cells

CDCP1 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01256

Species: Cynomolgus

Expression System: HEK293 Cells

CDCP1 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-01181

Species: Human

Expression System: HEK293 Cells

CDCP1 Protein, Human, Recombinant (aa 30-368, His)

Cat.No: TMPK-01183

Species: Human

Expression System: HEK293 Cells

CDCP1 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-01255

Species: Cynomolgus

Expression System: HEK293 Cells

CDCP1 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-01182

Species: Human

Expression System: HEK293 Cells

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